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Sunifiram is a research ampakine that is becoming very popular amongst researchers. As an ampakine, it works to improve the ability of the AMPA glutamate receptors. Sunifiram works by stimulating the AMPA receptor currents therefore improving the glutamate signal. This is believed to be the main method of action however there are several other applications of this compound.
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity - http http://www.ncbi.nlm.nih.gov/pubmed/11087574
Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. - http://www.ncbi.nlm.nih.gov/pubmed/23295391
Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. - http://www.ncbi.nlm.nih.gov/pubmed/23733502